The Encyclopedia Show, founded in Chicago by Robbie Q. Telfer and Shanny Jean Maney in December 2008, is a live variety extravaganza that commissions local and touring artists and experts from many disciplines to use their individual talents to present a verbal and musical encyclopedia entry each month. Though the show is accredited by the Institute of Human Knowledge and Hygiene, it is their ongoing mission to chafe against logic and proof, find meaning in obfuscation, and wrest truth from fact once and for all.

Led by Robbie Q. Telfer, the Encyclopedia Show partnered with the CCE in 2012 to create a show on the subject of Origins of Life Chemistry. They commissioned artists to create music and poetry on a variety of subtopics such as artificial chemical life, emergence, hydrothermal vents, and Titan. The show played twice: Chicago (May 2013) and as part of the Atlanta Science Festival in March 2014.

The shows were smashing successes. Bring tears of laughter and sadness to audience members, the performing artists were able to creatively communicate topics about the chemical origins of life, from a poem that compared the rise of RNA as an important biological molecule to Beyonce's rise to fame all the way to a spoof on the origins of life – Life cereal that is.